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                  副研究員
                  危平 副研究員
                  副研究員,博士
                  E-mail: weiping@fudan.edu.cn
                   

                    2005年畢業于復旦大學上海醫學院獲得臨床學士學位,2011年畢業于復旦大學生物醫學研究院獲得生物化學與分子生物學博士學位,2008-2011年在美國德州大學M.D.Anderson癌癥研究中心從事研究助理和博士后的工作。2011年8月任職于復旦大學附屬腫瘤醫院腫瘤研究所。獲得上海市啟明星,浦江人才計劃,上海市自然科學基金面上項目,獲得國家自然科學基金面上項目和青年項目,以子課題負責人參加國家973課題,以主要完成人參加國家重大專項、上海市科委基礎研究重大項目。獲得中國抗癌協會科技獎二等獎,上海市抗癌協會科技獎二等獎,獲得結腸癌、肺癌相關發明型專利兩項。研究成果發表于Cancer Cell, Cancer Research, Clinical Cancer Research等國際核心雜志。


                  研究領域:

                    惡性腫瘤侵襲轉移的分子機制及轉化性研究,主要研究方向如下:
                    1. 癌基因FoxM1在惡性腫瘤轉移中的機制研究;
                    2. 惡性腫瘤早診、預后和轉移預警相關的分子標志物的篩選和發病機制研究;
                    3. 肺癌和結直腸癌預后相關的分子分型模型研究。


                  代表性論著:

                  1. Zhang M, Weng W, Zhang Q, Wu Y, Ni S, Tan C, Xu M, Sun H, Liu C, Wei P*, Du X*.The lncRNA NEAT1 activates Wnt/β-catenin signaling and promotes colorectal cancer progression via interacting with DDX5. J Hematol Oncol, 2018;11(1):113.
                  2. Qingguo Li#, Ping Wei#, Jitao Wu#, Meng Zhang, Guichao Li, Yaqi Li, Ye Xu, Xinxiang Li, Dacheng Xie, Sanjun Cai, Keping Xie ,Dawei Li. The FOXC1/FBP1 signaling axis promotes colorectal cancer proliferation by enhancing the Warburg effect. Oncogene, 2018; 38(4):483~496.
                  3. Zhang M, Li G, Sun X, Ni S, Tan C, Xu M, Huang D, Ren F, Li D, Wei P*, Du X*. MET amplification, expression, and exon 14 mutations in colorectal adenocarcinoma. Hum Pathol, 2018 Apr 8. pii: S0046-8177(18)30115-1.
                  4. Wang YQ, Zhou XR,Xu MD, Weng WW, Zhang QY , Yang YS, Wei P*, Du X*. OTUB1-catalyzed deubiquitination of FOXM1 facilitates tumor progression and predicts a poor prognosis in ovarian cancer. Oncotarget, 2016; 7(24):36681-36697.
                  5. Li Q#, Wei P#, Huang B, Xu Y, Li X, Li Y, Cai S, Li D. MAEL expression links epithelial-mesenchymal transition and stem cell properties in colorectal cancer. Int J Cancer, 2016; 139(11):2502-11.
                  6. Wei P#, Zhang N#, Wang Y#, Li D, Wang L, Sun X, Shen C, Yang Y, Zhou X, Du X. FOXM1 Promotes Lung Adenocarcinoma Invasion and Metastasis by Upregulating SNAIL. International Journal of Biological Sciences, 2015; 11(2):186-98.
                  7. Liu Z#, Wei P#, Yang Y#, Cui W, Cao B, Tan C, Yu B, Bi R, Xia K, Chen W, Wang Y, Zhang Y, Du X, Zhou X. BATF2 deficiency promotes progression in human colorectal cancer via activation of HGF/MET signaling: a potential rationale for combining MET inhibitors with IFNs. Clinical Cancer Research, 2015; 21(7):1752-63.
                  8. Sun X#, Wei P#, Shen C, Yang Y, Wang Y, Li Y, Du X. Prognostic value of the?IASLC/ATS/ERS classification and IMP3?expression in lung adenocarcinoma of Chinese cases. American journal of Cancer Research, 2015; 5(7):2266-76.
                  9. Gong AH#, Wei P#, Zhang S#, Yao J, Yuan Y, Zhou AD, Lang FF, Heimberger AB, Rao G, Huang S. FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Self-Renewal and Tumorigenicity of Glioblastoma Stem-like Cells. Cancer Research, 2015; 75(11):2337-48.
                  10. Wei P#, Zhang N#, Xu Y, Li X, Shi D, Wang Y, Li D, Cai S. TPX2 is a novel prognostic marker for the growth and metastasis of colon cancer. Journal of Translational Medicine, 2013 Dec 17; 11:313.
                  11. Xia Z#, Wei P#, Zhang H, Ding Z, Yang L, Huang Z, Zhang N. AURKA governs self-renewal capacity in glioma-initiating cells via stabilization/activation of beta-catenin/Wnt signaling. Molecular Cancer Research, 2013; 11(9):1101-11.
                  12. Li D#, Wei P#, Peng Z, Huang C, Tang H, Jia Z, Cui J, Le X, Huang S, Xie K. The Critical Role of Dysregulated FOXM1 – PLAUR Signaling in Human Colon Cancer Progression and Metastasis. Clinical Cancer Research, 2013; 19(1):62-72.
                  13. Wei P#, Zhang W#, Yang LS#, Zhang HS, Xu XE, Jiang YH, Huang FP, Shi Q. Serum GFAP autoantibody as an ELISA-detectable glioma marker. Tumor Biology, 2013; 34(4):2283-92.
                  14. Zhang N#, Wei P#, Gong A, Chiu WT, Lee HT, Colman H, Huang H, Xue J, Liu M, Wang Y, Sawaya R, Xie K, Yung WK, Medema RH, He X, Huang S.FoxM1 promotes beta-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis. Cancer Cell, 2011; 20(4):427-42.
                   
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