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                  院士工作站

                  陳磊 研究員
                  研究員
                   

                    2002年本科畢業于復旦大學生命科學院,2007年研究生畢業于海軍軍醫大學。2015-2016在美國國立衛生研究院國家癌癥研究所訪問學者。2017年9月起任腫瘤研究所王紅陽院士工作站PI。2017年獲教育部青年長江學者,2015年獲國家基金委優秀青年科學基金,2015年所在集體獲軍隊一等功,2014年獲上海市青年科技英才(成果轉化類)和明治生命科學獎(二等獎),2013年獲第二軍醫大學優秀青年學者,2012年獲軍隊個人三等功,2008年獲上海市醫學科技一等獎(第三完成人)。兼任中國醫師協會臨床精準醫療專業委員會常務委員,上海醫學會分子診斷專委會青年委員會副主任委員,上海市遺傳學會理事。主要研究方向為肝臟惡性腫瘤早期預警和個體化診療。先后在Gastroenterology,Nature Communications,Gut,Cancer Research, Hepatology, Journal of Hepatology,BBA-reviews on Cancer,Nature Cell Biology,J.E.M,Gene & Development等學術期刊發表SCI論文50余篇,總引用次數2120次。發表第一作者/通訊作者SCI研究論文30篇,其中影響因子大于10分論文12篇。獲國家發明專利授權3項,申報國家發明專利6項。


                  研究領域:

                    1. 肝膽腫瘤早期預警標志物篩選、鑒定;
                    2. 肝膽腫瘤早期發生分子機制;
                    3. 腫瘤個體化治療分子機理及干預策略。


                  代表性論著:

                  1. Jiabin Cai#, Lei Chen#, Zhou Zhang#, Xinyu Zhang#, Xingyu Lu, Weiwei Liu, Guoming Shi, Yang Ge, Pingting Gao, Yuan Yang, Aiwu Ke, Linlin Xiao, Ruizhao Dong, Yanjing Zhu, Xuan Yang, Jiefei Wang, Tongyu Zhu, Deping Yang, Xiaowu Huang, Chengjun Sui, Shuangjian Qiu, Feng Shen, Huichuan Sun, Weiping Zhou, Jian Zhou, Ji Nie, Chang Zeng, Emily Kunce Stroup, Xu Zhang, Brian C-H Chiu, Wan Yee Lau, Chuan He*, Hongyang Wang*, Wei Zhang*, Jia Fan*. Genome-wide mapping of 5-hydroxymethylcytosines in circulating cell-free DNA as a non-invasive approach for early detection of hepatocellular carcinoma. Gut, 2019; 0:1–11. doi:10.1136/gutjnl-2019-318882.
                  2. Seogsong Jeon, Bo Zheng, Hongyang Wang*, Qiang Xia*, Lei Chen*. Nervous system and primary liver cancer. BBA-Reviews on Cancer, 2018 DOI:10.1016/j.bbcan.2018.04.002. (Review Article)
                  3. Xi-Meng Lin#, Liang Hu#, Jin Gu#, Ruo-Yu Wang#, Liang Li, Jing Tang, Bao-Hua Zhang, Xing-Zhou Yan, Yan-Jing Zhu, Cong-Li Hu, Wei-Ping Zhou, Frank J Gonzalez, Meng-Chao Wu, Hong-Yang Wang*, and Lei Chen*. Choline Kinase Alpha-Driven Assembly of EGFR and mTORC2 Promotes Hepatocellular Carcinoma Metastasis and Drug Resistance. Gastroenterology, 2017 Apr 1; 152:1187-1202.
                  4. RuoYu Wang#, Lei Chen#, HaiYang Chen#, Liang Hu, Liang Li, HanYong Sun, Feng Jiang, GaoMinyang Liu, Jing Tang, CaiYang Chen, YingCheng Yang, YanXin Chang, Hui Liu, Jin Zhang, Yuan Yang, MengChao Wu, Feng Shen, WeiPing Zhou*, and HongYang Wang*. MUC15 Inhibits Dimerization of EGFR and PI3K–AKT Signaling and Is Associated with Aggressive Hepatocellular Carcinomas in Patients. Gastroenterology, 2013 Dec; 145(6):1436-48.
                  5. Yingcheng Yang#, Ximeng Lin#, Xinyuan Lu#, Guijuan Luo#, Tao Zeng, Jing Tang, Feng Jiang, Liang Li, Xiuliang Cui, Wentao Huang,Guojun Hou, Xin Chen, Qing Ouyang, Shanhua Tang,Huanlin Sun,Luonan Chen,Mengchao Wu,Frank J. Gonzalez,Wenming Cong, Lei Chen*, Hongyang Wang*. Interferon-MicroRNA Signaling Drives Liver Precancerous Lesion Formation and Hepatocarcinogenesis. Gut, 2016 Jul;65(7):1186-201.
                  6. Liang Li#, Jing Tang#, Baohua Zhang#, Wen Yang, Haiyang Chen, Miyang Liu Gao, Ruoyu Wang, Yexiong Tan, Jianling Fan, Yanxin Chang, Jing Fu, Feng Jiang, Caiyang Chen, Yingcheng Yang, Dingming Wu, Ruiying Zheng, Hengyu Li, Baohua Zhang, Mengchao Wu, Michael.Q Zhang, Lei Chen* and Hongyang Wang*. Epigenetic Modification of miR-429 in Hepatocellular Carcinoma Manipulates EpCAM+ Liver Tumor-Initiating Cells Properties via Targeting RBBP4/E2F1/Oct4 Axis. Gut, 2015; 64:1156-167.
                  7. Yang Yang#, Lei Chen#, Jin Gu#, Hanshuo Zhang#, Jiapei Yuan, Qiuyu Lian, Guishuai, Siqi Wang, Yang Wu, Yu-Cheng T. Yang, Dongfang Wang, Yang Liu, Jing Tang, Guijuan Luo, Yang Li, Long Hu, Xinbao Sun, Dong Wang, Mingzhou Guo, Qiaoran Xi, Jianzhong Xi, Hongyang Wang*, Michael Q. Zhang*, and Zhi John Lu*. Recurrently deregulated lncRNAs in hepatocellular carcinoma. Nature Communication, 2017 Feb 13; 8:14421.
                  8. Qing Ou-Yang#, Xi-Meng Lin#, Yan-Jing Zhu#, Bo Zheng#, Liang Li, Ying-Cheng Yang, Guo-Jun Hou, Xin Chen, Gui-Juan Luo, Feng Huo, Qi-Bin Leng, Frank J Gonzalez, Xiao-Qing Jiang*, Hong-Yang Wang*, and Lei Chen*. Distinct Role of Nuclear Receptor Corepressor 1 Regulated de novo Fatty Acids Synthesisin Liver Regenerationand Hepatocarcinogenesis. Hepatology, 2017 March; 67(3):1071-1087.
                  9. Guojun Hou#, Lei Chen#, Gang Liu#, Liang Li, Yuan Yang, He-Xin Yan, Hui-Lu Zhang, Jing Tang, Ying Cheng Yang, Ximeng Lin, Xin Chen, Gui juan Luo, Yanjing Zhu, Shanhua Tang, Jin Zhang, Hui Liu, Qingyang Gu, Ling-Hao Zhao, Yixue Li, Lei Liu, Weiping Zhou*, Hongyang Wang*. Aldehyde Dehydrogenase-2 (ALDH2) Opposes HCC Progression by Regulating AMPK Signaling. Hepatology, 2017 May; 65(5):1628-1644.
                  10. Feng Jiang#, Lei Chen#, Ying-Cheng Yang#, Xian-Ming wang, Ruo-Yu Wang, Liang Li, Wen Wen, Yan-Xin Chang, Cai-Yang Chen, Jing Tang, Gao-Mi-Yang Liu, Wen-Tao Huang, Lin Xu*, and Hong-Yang Wang*. CYP3A5 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Regulating mTORC2/Akt Signalin. Cancer Research, 2015 Apr 1; 75(7):1470-81.
                  11. Yanxin Chang#, Chen Liu#, Jiahe Yang#, Gaomiyang Liu, Feiling Feng,Jing Tang, Liang Hu, Liang Li, Feng Jiang, Caiyang Chen, Ruoyu Wang, Yingcheng Yang, Xiaoqing Jiang, Mengchao Wu, Lei Chen* and Hongyang Wang*. MiR-20a Triggers Metastasis of Gallbladder Carcinoma. Journal of Hepatology, 2013 Sep; 59(3):518-27.
                   
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