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                  臨床PI
                  陳海泉 教授
                  教授,博士生導師
                  E-mail: hqchen1@yahoo.com
                   

                    陳海泉教授,醫學博士、主任醫師、二級教授、博導。復旦大學附屬腫瘤醫院胸外科主任、胸部腫瘤多學科首席專家、肺癌中心主任、復旦大學胸部腫瘤研究所所長。美國胸外科學會AATS會員(2011年起)及會員發展委員會委員(2016-2017年),美國胸外科醫師協會STS會員(2004年起)、國際理事(2016-2019年)及兩屆國際部委員(2011-2013、2014-2016年),美國胸科醫師學院資深會員(FCCP),歐洲胸外科醫師協會ESTS會員(2015年起),亞洲胸心血管外科協會 ASCVTS 理事(2016年起),中國胸外科醫師協會副會長,上海胸外科學會副主任委員,上海市抗癌協會胸部腫瘤委員會主任委員。Journal of Cancer Research and Clinical Oncology副主編,Journal of Thoracic and Cardiovascular Surgery、American Journal of Translational Research、Journal of Thoracic Disease編委。


                  主持包括“國家自然科學基金重點項目及面上項目,“上海市科委重點項目,“上海衛生系統重要疾病聯合攻關項目等多項科研項目。作為第一和通訊作者在Cancer Cell、JCO、CCR、JTO、ANN SURG、CHEST、Cancer、JTCVS、ANN THORAC SURG等學術期刊上發表SCI收錄論文150多篇。截止至2017年共有11篇、13篇次論文的創新成果納入ASCO、ESMO、IASLC等7項國際肺癌診治、分子檢測指南。曾獲中國抗癌協會科技獎一等獎、上海市科技進步獎一等獎一項、二等獎兩項、三等獎一項,華夏醫學科技獎一等獎一項,中華醫學科技獎一等獎一項,軍隊醫療成果二等獎一項、上海醫學科技二等獎一項、專利三項、第三屆國之名醫“卓越建樹稱號”。


                  研究領域:

                    肺癌分子生物標志的轉化性研究

                  研究團隊:

                    陳海泉教授研究團隊由臨床醫生、科研秘書、專職實驗人員及在讀博士、碩士研究生組成。團隊研究以肺癌靶向治療為重點,本著“From bedside to bench, From bench to bedside”的研究理念,積極將研究成果向臨床應用轉化。團隊目前主要研究方向為發現新型可作為治療靶點的基因突變,以及致癌基因突變相關靶向治療耐藥機制研究。通過采用二代測序、Ion Torrent測序、直接測序法,我們團隊對非小細胞肺癌致癌基因突變譜進行解讀,并在國際上率先定義了ROS1和RET融合基因。通過整合細胞體外實驗、動物模型構建、臨床標本及預后隨訪,我們建立了完善的轉化醫學研究平臺,培養了眾多的碩、博士研究生。


                  代表性論著:

                  1. Fu F, Zhang Y, Wen Z, Zheng D, Gao Z, Han H, Deng L, Wang S, Liu Q, Li Y, Shen L, Shen X, Zhao Y, Zhao Z, Ye T, Xiang J, Zhang Y, Sun Y, Hu H, Chen H*. Distinct Prognostic Factors in Patients with Stage I Non-Small Cell Lung Cancer with Radiologic Part-Solid or Solid Lesions. J Thorac Oncol, 2019 Aug 19. pii: S1556-0864(19)30664-1.
                  2. Pan Y, Zhang Y, Ye T, Zhao Y, Gao Z, Yuan H, Zheng D, Zheng S, Li H, Li Y, Jin Y, Sun Y, Chen H*. Detection of Novel NRG1, EGFR, and MET Fusions in Lung Adenocarcinomas in the Chinese Population. J Thorac Oncol, 2019 Aug 2. pii: S1556-0864(19)30652-5.
                  3. Ma X, Li B, Li Y, Lu L, Chen H*. A Pathologic Complete Response to Neoadjuvant Chemotherapy and Immunotherapy Followed by Surgery in a Patient With NSCLC. J Thorac Oncol, 2019 May; 14(5):e104-e106.
                  4. Ye T, Deng L, Wang S, Xiang J, Zhang Y, Hu H, Sun Y, Li Y, Shen L, Xie L, Gu W, Zhao Y, Fu F, Peng W, Chen H*. Lung Adenocarcinomas Manifesting as Radiological Part-Solid Nodules Define a Special Clinical Subtype. J Thorac Oncol, 2019 Apr; 14(4):617-627.
                  5. Li B, Hu H, Zhang Y, Zhang J, Miao L, Ma L, Luo X, Zhang Y, Ye T, Li H, Zhou J, Li Y, Shen L, Zhao K, Fan M, Zhu Z, Wang J, Xu J, Deng Y, Lu Q, Jia H, Cheng X, Li H, Zhang Y, Li C, Pan Y, Liu S, Hu H, Shao L, Sun Y, Xiang J, Chen H*. Extended Right Thoracic Approach Compared With Limited Left Thoracic Approach for Patients With Middle and Lower Esophageal Squamous Cell Carcinoma: Three-year Survival of a Prospective, Randomized, Open-label Trial. Ann Surg, 2018 May; 267(5):826-832.
                  6. Cheng X, Onaitis MW, D'amico TA, Chen H*. Minimally Invasive Thoracic Surgery 3.0. Ann Surg, 2018 Jan; 267(1):37-38.
                  7. Zhao Y, Li G, Zhang Y, Hu H, Zhang J, Sun Y, Chen H*.Comparison of outcomes between muscle-sparing thoracotomy and video-assisted thoracic surgery in patients with cT1 N0 M0 lung cancer. J Thorac Cardiovasc Surg, 2017 Oct; 154(4):1420-1429.e1.
                  8. Zhao Y, Li G, Zheng D, Jia M, Dai W, Sun Y, Chen H*.The prognostic value of lymph node ratio and log odds of positive lymph nodes in patients with lung adenocarcinoma. J Thorac Cardiovasc Surg, 2017 Mar; 153(3):702-709.e1.
                  9. Cheng X, Onaitis MW, D'amico TA, Chen H*. Minimally invasive thoracic surgery 3.0: lessons learned from the history of lung cancer surgery. Ann Surg, 2018 Jan; 267(1):37-38.
                  10. Liu S, Wang R, Zhang Y, Li Y, Cheng C, Pan Y, Xiang J, Zhang Y, Chen H*, Sun Y*. Precise Diagnosis of Intraoperative Frozen Section Is an Effective Method to Guide Resection Strategy for Peripheral Small-Sized Lung Adenocarcinoma. J Clin Oncol, 2016 Feb 1; 34(4):307-13.
                  11. Huang Q, Li J, Sun Y, Wang R, Cheng X, Chen H*. Efficacy of EGFR tyrosine kinase inhibitors in the adjuvant treatment for operable non-small-cell lung cancer by a meta-analysis. Chest, 2016 Jun; 149(6):1384-92.
                  12. Li C, Gao Z, Li F, Li X, Sun Y, Wang M, Li D, Wang R, Li F, Fang R, Pan Y, Luo X, He J, Zheng L, Xia J, Qiu L, He J, Ye T, Zhang R, He M, Zhu M, Hu H, Shi T, Zhou X, Sun M, Tian S, Zhou Y, Wang Q, Chen L, Yin G, Lu J, Wu R, Guo G, Li Y, Hu X, Li L, Asan, Wang Q, Yin Y, Feng Q, Wang B, Wang H, Wang M, Yang X, Zhang X, Yang H, Jin L, Wang CY, Ji H*, Chen H*, Wang J, Wei Q*. Whole Exome Sequencing Identifies Frequent Somatic Mutations in Cell-Cell Adhesion Genes in Chinese Patients with Lung Squamous Cell Carcinoma. Sci Rep, 2015 Oct 27; 5:14237.
                  13.  Li H, Hu H, Wang R, Li Y, Shen L, Sun Y, Chen H*. Lung adenocarcinoma: Are skip N2 metasasis different from non-skip? J Thorac Cardiovasc Surg, 2015 Oct; 150(4):790-5.
                  14. Zhang Y, Wang R, Li Y, Pan Y, Hu H, Zhang Y, Li H, Shen L, Yu Y, Sun Y*, Chen H*. Negative Thyroid Transcription Factor 1 (TTF1) Expression Defines an Unfavorable Subgroup of Lung Adenocarcinomas. J Thorac Oncol, 2015 Oct; 10(10):1444-50.
                  15. Cheng C, Wang R, Li Y, Pan Y, Zhang Y, Li H, Zheng D, Zheng S, Shen X, Sun Y*, Chen H*. EGFR Exon 18 Mutations in East Asian Patients with Lung Adenocarcinomas: A Comprehensive Investigation of Prevalence, Clinicopathologic Characteristics and Prognosis. Sci Rep, 2015 Sep 10; 5:13959.
                  16. Zhang Y, Zhang Y, Chen S, Li Y, Yu Y, Sun Y*, Chen H*. Is bronchoscopy necessary in the preoperative workup of a solitary pulmonary nodule? J Thorac Cardiovasc Surg, 2015 Jul; 150(1):36-40.
                  17. Li F, Han X, Li F, Wang R, Wang H, Gao Y, Wang X, Fang Z, Zhang W, Yao S, Tong X, Wang Y, Feng Y, Sun Y, Li Y, Wong KK, Zhai Q, Chen H*, Ji H*. LKB1 Inactivation Elicits a Redox Imbalance to Modulate Non-small Cell Lung Cancer Plasticity and Therapeutic Response. Cancer Cell, 2015 May 11; 27(5):698-711.
                  18. Li B, Xiang J, Zhang Y, Li H, Zhang J, Sun Y, Hu H, Miao L, Ma L, Luo X, Chen S, Ye T, Zhang Y, Zhang Y, Chen H*. Comparison of Ivor-Lewis vs Sweet Esophagectomy for Esophageal Squamous Cell Carcinoma: A Randomized Clinical Trial. JAMA Surgery, 2015 Apr; 150(4):292-8.
                  19. Xiao Ma, Ranxia Gong, Rui Wang, Yunjian Pan, Deng Cai, Bin Pan, Yuan Li, Jiaqing Xiang, Hecheng Li, Jie Zhang, Yihua Sun*, Haiquan Chen*. Recurrent TERT promoter mutations in non-small cell lung cancers. Lung Cancer, 2014 Oct 23; 86(3):369-373.
                  20. Zhang Y, Li J, Wang R, Li Y, Pan Y, Cai D, Hu H, Li H, Ye T, Luo X, Zhang Y, Li B, Shen L, Sun Y*, Chen H*. The prognostic and predictive value of solid subtype in invasive lung adenocarcinoma. Scientific Reports, 2014 Nov 24; 4:7163.
                  21.  Zhang Y, Wang R, Cai D, Li Y, Pan Y, Hu H, Wang L, Li H, Ye T, Luo X, Zhang Y, Li B, Shen L, Sun Y, Chen H*. A comprehensive investigation of molecular features and prognosis of lung adenocarcinoma with micropapillary component. J Thorac Oncol, 2014 Dec; 9(12):1772-8.
                  22. Wang R, Pan Y, Li C, Zhang H, Garfield D, Li Y, Ye T, Hu H, Luo X, Li H, Zhang Y, Zhang J, Zhou X, Shen L, Pao W, Sun Y, Chen H*. Analysis of major known driver mutations and prognosis in resected adenosquamous lung carcinomas. J Thorac Oncol, 2014 Jun; 9(6):760-8.
                  23. Rui Wang, Lei Wang, Yuan Li, Haichuan Hu, Lei Shen, Xu-Xia Shen, Yunjian Pan, Ting Ye, Yang Zhang, Xiaoyang Luo, Yiliang Zhang, Bin Pan, Bin Li, Hang Li, Jie Zhang, William Pao, Hongbin Ji, Yihua Sun, Haiquan Chen*. FGFR1/3 tyrosine kinase fusions define a unique molecular subtype of Non-small Cell Lung Cancer. Clin Cancer Res, 2014 Aug 1; 20(15):4107-14.
                  24. Lei Wang, Haichuan Hu, Yunjian Pan, Rui Wang, Yuan Li, Lei Shen, Yongfu Yu, Hang Li, Deng Cai, Yihua Sun*, Haiquan Chen*. PIK3CA Mutations Frequently Coexist with EGFR/KRAS Mutations in Non-Small Cell Lung Cancer and Suggest Poor Prognosis in EGFR/KRAS Wildtype Subgroup. Plos One, 2014 Feb; 9(2): e88291.
                  25. Zhang Y, Sun Y, Xiang J, Zhang Y, Hu H, Chen H*. A clinicopathologic prediction model for postoperative recurrence in stage Ia non-small cell lung cancer. J THORAC CARDIOV SUR, 2014 Oct; 148(4):1193-9.
                  26. Yunjian Pan, Yang Zhang, Yuan Li, Haichuan Hu, Lei Wang, Hang Li, Rui Wang, Ting Ye, Xiaoyang Luo, Yiliang Zhang, Bin Li, Deng Cai, Lei Shen, Yihua Sun, Haiquan Chen*. ALK, ROS1 and RET fusions in 1139 lung adenocarcinomas: a comprehensive study of common and fusion pattern-specific clinicopathologic, histologic and cytologic features. Lung Cancer, 2014 May; 84(2):121–126.
                  27. Pan Y, Wang R, Ye T, Li C, Hu H, Yu Y, Zhang Y, Wang L, Luo X, Li H, Li Y, Shen L, Sun Y, Chen H*. Comprehensive Analysis of Oncogenic Mutations in Lung Squamous Cell Carcinoma with Minor Glandular Component. Chest, 2014 Mar 1;145(3):473-9.
                  28. Wang Z, Sun Y, Gao B, Lu Y, Fang R, Gao Y, Xiao T, Liu XY, Pao W, Zhao Y, Chen H*, Ji H*. Two co-existing germline mutations P53 V157D and PMS2 R20Q promote tumorigenesis in a familial cancer syndrome. Cancer Lett, 2014 Jan 1; 342(1):36-42.
                  29. Fang R, Zheng C, Sun Y, Han X, Gao B, Li C, Liu H, Wong KK, Liu XY*, Chen H*, Ji H*. Brief Report: Integrative genomic analysis reveals a high frequency of LKB1 genetic alteration in Chinese lung adenocarcinomas. J Thorac Oncol, 2014 Feb; 9(2):254-8.
                  30. Hang Li, Yunjian Pan, Yuan Li, Chenguang Li, Rui Wang, Haichuan Hu, Yang Zhang, Ting Ye, Lei Wang, Lei Shen, Yihua Sun*, Haiquan Chen*. Frequency of well-identified oncogenic driver mutations in lung adenocarcinoma of smokers varies with histological subtypes and graduated smoking dose. Lung Cancer, 2013 Jan; 79(1):8-13.
                  31. Yuan Li, Yunjian Pan, Rui Wang, Yihua Sun, Haichuan Hu, Xuxia Shen, Yongming Lu, Lei Shen, Xiongzeng Zhu*, Haiquan Chen*. ALK-Rearranged Lung Cancer in Chinese: A Comprehensive Assessment of Clinicopathology, IHC, FISH and RT-PCR. PLoS ONE, Jul 26; 8(7):e69016.
                  32. Bin Li, Haiquan Chen*, Jiaqing Xiang, Yawei Zhang, Yunyi Kong, David H. Garfield and Hecheng Li. Prevalence of lymph node metastases in superficial esophageal squamous cell carcinoma. J Thorac Cardiovasc Surg, 2013 Nov; 146:1198-203.
                  33. Zhang J, Garfield D, Jiang Y, Wang S, Chen S, Chen H*. Does sex affect survival of squamous cell esophageal cancer patients? J Clin Oncol, 2013 Feb 20; 31(6):815-6.
                  34. Rui Wang, Haichuan Hu, Yihua Sun, Haiquan Chen* et al. RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer. J Clin Onco, 2012 Dec; 30:4352-4359.
                  35. Zhang Y, Sun Y, Pan Y, Li C, Shen L, Li Y, Luo X, Ye T, Wang R, Hu H, Li H, Wang L, Pao W, Chen H*. Frequency of driver mutations in lung adenocarcinoma from female never-smokers varies with histologic subtypes and age at diagnosis. Clin Cancer Res, 2012 Apr 1; 18(7):1947-53.
                  36. Wang R, Pan Y, Li C, Chen H* et al. The Use of Quantitative Real-Time Reverse Transcriptase PCR for 5' and 3' Portions of ALK Transcripts to Detect ALK Rearrangements in Lung Cancers. Clin Cancer Res, 2012 Sep 1; 18(17):4725-32.
                  37. Li B, Chen H*, Xiang J, Zhang Y, Li C, Hu H, Zhang Y. Pattern of lymphatic spread in thoracic esophageal squamous cell carcinoma: A single-institution experience. J Thorac Cardiovasc Surg, 2012 Oct; 144(4):778-86.
                  38. Zhang Y, Sun Y, Xiang J, Zhang Y, Hu H, Chen H*. A prediction model for N2 disease in T1 non-small cell lung cancer. J Thorac Cardiovasc Surg, 2012 Dec; 144:1360-1364.
                  39. Fei Li, Yan Feng, Rong Fang, Zhaoyuan Fang, Jufeng Xia, Xiangkun Han, Haiquan Chen*, Hongyan Liu*, Hongbin Ji*. Identification of RET gene fusion by exon array analyses in "pan-negative" lung cancer from never smokers. Cell Res, 2012 May; 22(5):928-31.
                  40. Sun Y, Ren Y, Fang Z, Li C, Fang R, Gao B, Han X, Tian W, Pao W, Chen H*, Ji H. Lung adenocarcinomas with HER2 activating mutations are associated with distinct clinical features and HER2/EGFR copy number gains. J Thorac Oncol, 2012 Jan; 7(1):85-9.
                  41. Li C, Sun Y, Fang ZY, Han XK, Fang R, Zhang Y, Pan Y, Zhang W, Ji H, Chen H*. Comprehensive Analysis of Epidermal Growth Factor Receptor (EGFR) Gene Status in Lung Adenocarcinoma. J Thorac Oncol, 2011 Jun; 6(6):1016-21.
                  42. Wang R, Zhang J, Chen S, Lu M, Luo X, Yao S, Liu S, Qin Y, Chen H*. Tumor-associated macrophages provide a suitable microenvironment for non-small lung cancer invasion and progression. Lung Cancer, 2011 Nov; 74(2):188-96.
                  43. Sun Y, Ren Y, Fang Z, Li C, Fang R, Gao B, Han X, Tian W, Pao W*, Chen H*, Ji H*. Lung Adenocarcinoma From East Asian Never-Smokers Is a Disease Largely Defined by Targetable Oncogenic Mutant Kinases. J Clin Oncol, 2010; Oct 20;28(30):4616-20.
                  44. Ye T, Chen H*, Hu H, Wang J, Shen L. Malignant clear cell sugar tumor of the lung: Patient case report. J Clin Oncol, 2010 Nov 1; 28(31):e626-8.
                  45. Zhang J, Chen SF, Zhen Y, Xiang J, Wu C, Bao P, Luketich J, Hu H, Zhou X, Zhang J, Yao S, Chen HQ*. Multicenter analysis of lung cancer patients younger than 45 years in Shanghai. Cancer, 2010 Aug 1;116(15):3656-62


                   
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