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                  專職PI
                  梁琳慧 副研究員
                  副研究員,博士
                  E-mail: lianglinhui@fudan.edu.cn
                   

                    2006年畢業于中國協和醫科大學血液學研究所,獲內科學博士。2006年至2012年在上海市腫瘤研究所癌基因及相關基因國家重點實驗室工作,2013年至今在復旦大學生物醫學研究院/復旦大學附屬腫瘤醫院工作。主要研究方向為非編碼RNA在腫瘤發生發展中的作用和分子機制。近5年曾主持項目包括國家“十一五”,“十二五”重大專項子課題,上海市自然科學基金,上海市衛生局新優青人才計劃,上海市衛生局青年基金,上海市青年科技啟明星人才計劃等。目前承擔國家自然科學基金兩項。近5年發表論著25篇,主要發表在Hepatology, Oncogene, Theranostics等國際著名專業期刊上。相關研究內容獲教育部自然科學獎二等獎一項(排名第二),上海醫學獎二等獎一項(排名第二)。


                  研究領域:

                    消化系統惡性腫瘤發病的分子機制研究,主要是非編碼RNA在腫瘤發生與轉移中的功能、作用機制和臨床轉化。


                  代表性論著:

                  1. Wu Y, Zhou Y, Huan L, Xu L, Shen M, Huang S, Liang L. LncRNA MIR22HG inhibits growth, migration and invasion through regulating the miR-10a-5p/NCOR2 axis in hepatocellular carcinoma cells. Cancer Sci,2019; 110(3):973-984.
                  2. Hui Wang#, Linhui Liang#, Qiongzhu Dong #, Lin Huan, Jia He, Botai Li, Chen Yang, Haojie Jin, Lin Wei, Chengtao Yu, Fangyu Zhao, Jinjun Li, Ming Yao, Wenxin Qin*, Lunxiu Qin*, Xianghuo He*. Theranostics, 2018; 8 (10):2814-2829.
                  3. Lian Junwei#, Jing Ying#, Dong Qiongzhu#, Huan Lin, Chen Di, Bao Chunyang, Wang Qifeng, Zhao Fangyu, Li Jinjun, Yao Ming, Qin Lunxiu, Liang Linhui*, He Xianghuo*. miR-192, a prognostic indicator, targets the SLC39A6/SNAIL pathway to reduce tumor metastasis in human hepatocellular carcinoma. Oncotarget, 2016; 7(3):2672-2683.
                  4. Yu zhang#, jian yao#, lin huan, junwei lian, chunyang bao, yan li, chao ge, jinjun li, ming ya, linhui liang*, xianghuo he*. GNAI3 inhibits tumor cell migration and invasion and is posttranscriptionally regulated by miR-222 in hepatocellular carcinoma. Cancer Letters, 2015; 356:978-984.
                  5. Huan Lin, Bao Chunyang, Chen Di, Li Yan, Lian Junwei, Ding Jie, Huang Shenglin, Liang Linhui*, He Xianghuo*. MiR-127-5p targets the biliverdin reductase B/NF-kappaB pathway to suppress cell growth in hepatocellular carcinoma cells. Cancer Science, 2016 Mar; 107(3):258-66.
                  6. Ying Q#, Liang L#, Guo W, Zha R, Tian Q, Huang S, Yao J, Ding J, Bao M, Ge C, Yao M, Li J, He X*. Hypoxia-inducible microRNA-210 augments the metastatic potential of tumor cells by targeting vacuole membrane protein 1 in hepatocellular carcinoma. Hepatology, 2011; 54(6): 2064-2075.
                  7. Liang L, Wong CM, Ying Q, Fan DN, Huang S, Ding J, Yao J, Yan M, Li J, Yao M, Ng IO, He X*. MicroRNA-125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2. Hepatology, 2010; 52(5):1731-1740.
                  8. Zheng B#, Liang L#, Huang S, Zha R, Liu L, Jia D, Tian Q, Wang Q, Wang C, Long Z, Zhou Y, Cao X, Du C, Shi Y*, He X*. MicroRNA-409 suppresses tumour cell invasion and metastasis by directly targeting radixin in gastric cancers. Oncogene, 2012; 31(42):4509-16.
                  9. Liang L, He X*. Macro-management of microRNAs in cell cycle progression of tumor cells and its implications in anti-cancer therapy. Acta Pharmacol Sin, 2011; 32(11):1311-20.
                  10. Yao J#, Liang L#, Zhang Y, Ding J, Tian Q, Li JJ, He XH. GNAI1 Suppresses Tumor Cell Migration and Invasion and is Post-Transcriptionally Regulated by Mir-320a/c/d in Hepatocellular Carcinoma. Cancer Biology and medicine, 2012; 9(4):234-241.
                  11. Yao J, Liang L, Huang S, Ding J, Tan N, Zhao Y, Yan M, Ge C, Zhang Z, Chen T, Wan D, Yao M, Li J, Gu J, He X*. MicroRNA-30d Promotes Tumor Invasion and Metastasis by Targeting Galphai2 in Hepatocellular Carcinoma. Hepatology, 2010; 51(3):846-856.
                  12. Ke G, Liang L, Yang JM, Huang X, Han D, Huang S, Zhao Y, Zha R, He X, Wu X. MiR-181a confers resistance of cervical cancer to radiation therapy through targeting the pro-apoptotic PRKCD gene. Oncogene, 2013; 32(25):3019-27.
                  13. Zheng B, Liang L, Wang C, Huang S, Cao X, Zha R, Liu L, Jia D, Tian Q, Wu J, Ye Y, Wang Q, Long Z, Zhou Y, Du C, He X, Shi Y. MicroRNA-148a suppresses tumor cell invasion and metastasis by downregulating ROCK1 in gastric cancer. Clin Cancer Res, 2011; 17(24):7574-83.
                  14. Tian Q,Liang L, Ding J, Zha R, Shi H, Wang Q, Huang S, Guo W, Ge C, Chen T, Li J, He X*. MicroRNA-550a acts as a pro-metastatic gene and directly targets cytoplasmic polyadenylation element-binding protein 4 in hepatocellular carcinoma. PLoS One, 2012; 7(11):e48958.
                   
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